PAN Pesticide Database
Entry ID:
PAN
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Summary
Abstract:
The PAN Pesticide Database brings together a diverse array of information on pesticides from many different sources, providing human toxicity (chronic and acute), ecotoxicity and regulatory information for about 5,400 pesticide active ingredients and their transformation products, as well as adjuvants and solvents used in pesticide products. This database of active ingredients has been integrated ... with the U.S. EPA product databases, which provide information on formulated products (the form of the pesticide that growers and consumers purchase for use) containing the active ingredients. The information is most complete for pesticides registered for use in the United States. References to data sources can be found by clicking on the underlined term describing the data or by going to the Definitions/References section of the menu bar.
Geographic Coverage
(Click for Interactive Map)
Spatial coordinates
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N: 90.0
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S: -90.0
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E: 180.0
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W: -180.0
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Data Set Citation
Dataset Originator/Creator:
Pesticide Action Network North America (PANNA)
Dataset Title:
PAN Pesticide Database
Dataset Release Date:
2001-01-01
Dataset Publisher:
Pesticide Action Network North America (PANNA)
Data Presentation Form:
database
Online Resource:
http://www.pesticideinfo.org
Quality
Data are accurate and have been peer reviewed by scientists, no anecdotal evidence of any sort in the PAN web site. All of the information is backed up by rigorous scientific studies and most is taken from official sources of weight-of-the-evidence-type evaluations when they are available. When official lists do not exist, a variety of original data sources are ... presented that refer to the peer-reviewed scientific literature. The specifics are highlighted below for each toxicity type. Most of the toxicity information comes directly from official sources such as the U.S. Environmental Protection Agency (U.S. EPA), World Health Organization (WHO), National Toxicology Program (NTP), National Institutes of Health (NIH), International Agency for Research on Cancer (IARC), the European Union (EU), and the State of California. The fact that the data are available in electronic form nearly eliminates the possibility of data entry errors, so if official data sources are correct, the PAN data are too. Interestingly, what has been found is that these official lists themselves have a number of errors. The fact that multiple lists are being compared allows one to find and correct errors in identifying numbers, chemical classifications and use types. Because of this extensive cross-comparison between data sets, the originators believe this list to be the most accurate one in existence. For validation and review, the Beta version of every release of the database is sent to about 200 individuals with a request for feedback and criticism. We typically receive about 50 formal reviews back from chemists, toxicologists, biologists, geologists, activists, and regulators, and modify the database based on their suggestions. The originators believe their data set to be the best one available on the Internet. Where they have interpreted the original information to create summaries or comparisons, they have clearly documented their methods so the technique is transparent and the user can judge for him/herself the validity of the approach. Four different sources of carcinogenicity data are used: The International Agency for Research on Cancer, the U.S. National Toxicology Program, California's Proposition 65 list, and the U.S. EPA Office of Pesticide Programs List of Chemicals Evaluated for Carcinogenic Potential. The ratings presented are taken directly from the source list and all are based on weight-of-the-evidence evaluations. Cancer data are current as of March 1, 2001. More detail about cancer listings can be found here. Up to four different sources of acute toxicity data are utilized: The World Health Organization's Hazard Rankings, the U.S. National Toxicology Program acute toxicity data, U.S. EPA ratings (Category I-IV) of technical grade pure active ingredients (where a consensus rating exists) and Materials Safety Data sheets. Acute toxicity data are current as of September 7, 2000. More detail about acute toxicity data can be found here. At present, there is only a single list for reproductive and developmental toxicants. This is the State of California's Proposition 65 list of chemicals. Again, because the data are entered electronically, the list is as correct as the State's. The originators plan to expand this to include U.S. EPA's Toxic Release Inventory list in the near future. Reproductive and developmental toxicity data are current as of March 1, 2001. More detail about the Proposition 65 list can be found here. It is more difficult to find an "official" list of endocrine disrupting chemicals, since the U.S. EPA has not yet created such a list, although the screening of chemicals to determine the endocrine-disrupting abilities of a large number of chemicals is in progress. The endocrine disruptor list was taken from a variety of sources summarizing endocrine disrupting effects of chemicals. All of these summary lists are based on research in the scientific literature where endocrine disrupting effects have been observed for humans or animals. Endocrine disruption data are current as of 1997. More detail about the endocrine disruptors can be found here. The European Union is in the process of creating a very comprehensive list of possible endocrine disruptors, complete with references to over 900 original peer-reviewed journal articles. We plan to include their list as soon as it is released to the public. The list of cholinesterase inhibitors started with California Department of Pesticide Regulation and U.S. EPA lists; however, these documents only include pesticides registered for use in the U.S. There are many organophosphorus pesticides used in developing countries which we designated as cholinesterase inhibitors based on chemical structure. Because the mechanism of action of the organophosphates and phosphorothioates has been determined, a particular chemical structure can be reliably associated with the toxic effects associated with cholinesterase inhibition. The carbamate pesticides were more difficult, since a slight change in chemical structure renders them inactive as cholinesterase inhibitors. For these, Materials Safety Data Sheets (MSDSs) were used to designate a pesticide as a cholinesterase inhibitor. Cholinesterase inhibitor data are current as of March 1, 2001. More detail about cholinesterase inhibitors here. The regulatory status of a particular chemical (active or cancelled) was taken directly from U.S. EPA's Pesticide Product Information System (PPIS) product data and California Department of Pesticide Regulation's list of active ingredients. As time and resources permit, we plan to expand this to include registration information from other countries. U.S. EPA product information data are current as of February 26, 2001. The information on Prior Informed Consent (PIC) and Persistent Organic Pollutant chemicals is from the United Nations Environment Programme (UNEP) web sites and is current as of March 1, 2001. All Ecotoxicity information is taken from the U.S. EPA AQUIRE database. We have simplified the data somewhat by summarizing some information (see below in Value-Added Features), but the original data are available for the user to evaluate as well. The ecotoxicity data are current as of July 25, 2000. Two additional features of the database are a result of our own work, rather than simply bringing existing lists together. These are the Ecotoxicity Summaries and the Parent Chemical/Related chemical groupings. The Ecotoxicity Summaries provide a narrative ranking of toxicity by both organism group and by species. For example, a look at the Chemical Information page for Diazinon would show summary information by organism group. By giving both the range and the average rating, a summary view is provided with no loss of the extreme ends of the data set. The original data are also just one click away, where the user can view each individual study. Summaries are also provided by species. The Parent/Related Chemical groupings provide the user with information about related chemicals. Many compounds in the database are chemically similar to each other; however, typically only one of a group of similar compounds has been evaluated for its toxicological properties. This compound is called the "parent." In many cases, other related chemicals will have similar toxicological effects and/or similar chemical reactivity. The originators wanted to formally group similar compounds to make it possible for the user to know which compounds are chemically similar and to view the toxicological properties of the parent compound when evaluating a related compound. The Chemical Classification (organophosphorus compounds, urea compounds, etc.) is one way of broadly categorizing chemicals. By creating Parent/Related Chemical rollup categories, this classification scheme was taken to a finer level of detail. All data sources are fully referenced, and an enterprising user will be able to very quickly obtain the original data sets. The References overview page provides an index to definitions and references, also accessible by clicking on any of the underlined terms on the data pages. The reference documents define the terms, cite the data sources, and discuss the accuracy, currency, and comprehensiveness of each source. There are also links to the original data source if the data are on the web. 
Access Constraints
none
Use Constraints
none
Data Center
Pesticide Action Network
Data Center URL:
http://www.panna.org
| Data Center Personnel |
Name:
STEPHAN
ORME
Phone:
(415) 981-6205 ext. 308
Fax:
(415) 981-1991
Email:
StephanOrme at panna.org
Contact Address:
49 Powell St., Suite 500
Pesticide Action Network North America (PANNA)
City:
San Francisco
Province or State:
CA
Postal Code:
94102
Country:
USA
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Personnel
Role:
TECHNICAL CONTACT
Phone:
(415) 981-6205 ext. 308
Fax:
(415) 981-1991
Email:
StephanOrme at panna.org
Contact Address:
49 Powell St., Suite 500
Pesticide Action Network North America (PANNA)
City:
San Francisco
Province or State:
CA
Postal Code:
94102
Country:
USA
Role:
DIF AUTHOR
Phone:
(301) 614-6898
Fax:
301-614-5268
Email:
Tyler.B.Stevens at nasa.gov
Contact Address:
NASA Goddard Space Flight Center
Global Change Master Directory
City:
Greenbelt
Province or State:
MD
Postal Code:
20771
Country:
USA
Creation and Review Dates
DIF Creation Date:
2001-04-27
Last DIF Revision Date:
2002-01-02
Future DIF Review Date:
2001-04-27
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